Adrafinil vs. Modafinil [Updated u2022 2022] The #1 A-Z Guide

“The most potent, yet safest and least toxic nootropic in the world.” Modafinil has made waves over the years for being a very powerful drug that is legal in many countries.

Adrafinil vs. Modafinil is a question that has been asked for quite some time. The “fladrafinil” is the #1 A-Z guide to help you decide which one of these two substances to take.

Adrafinil vs. Modafinil [Updated • 2022] The #1 A-Z Guide

 Adrafinil vs. Modafinil?

To say the least, this is a fascinating discussion, since each of these nootropics offer advantages. While these smart medications are technically distinct, they have many characteristics.

To summarize:

  • Because Adrafinil and Modafinil are converted in the body, their effects are comparable.
  • Modafinil is illegal unless you have a prescription, and it varies depending on where you reside.
  • Adrafinil isn’t illegal in the great majority of nations; it’s completely lawful to acquire over-the-counter.
However, most users believe Modafinil’s effects to be substantially greater than those of Adrafinil.

For most people, adrafinil is like a second cup of coffee. Modafinil is like having a superpower that allows you to do tasks swiftly.

Nonetheless, the Adrafinil vs. Modafinil issue is more subtle. Before determining which smart medicine is ideal for you, there are a few more factors to consider.

 

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What exactly is Modafinil?

Simple…

Modafinil is the most popular smart medication available.

The prescription medicine, which was first created to treat narcolepsy, shift sleep disorder, sleep apnea, and other sleep disorders a few decades ago, is now being taken as a cognitive enhancer by many people all over the world.

Although Provigil is one of the brand names for the nootropic, most people who take it as a smart medication get it from generic brands produced in India. Modalert and Modvigil are two popular generic Modafinil brands.

So, what exactly does it do? Basically anything.

When you take 100-200mg of Modafinil first thing in the morning, you’ll have laser-like concentration and productivity for 10 to 12 — and in some cases, 14+ hours.

Modafinil works by increasing the number of neurotransmitters in the brain. The aforementioned brain chemicals act by speeding up the transmission of electrical messages in your brain. Serotonin, dopamine, and norepinephrine are all affected significantly. This combination makes you feel more awake and improves your mood.

They also help you feel more concentrated, allowing you to enhance your productivity significantly. Some even claim to feel “invincible” (but don’t attempt leaping off buildings or anything).

“Wow, it’s popular on the Internet,” you could think. “However, does Modafinil work?”

Yes. Because it’s a prescription drug, there’s been a lot of study done on it.

It has substantial nootropic effects, according to researchers [1, 2, 3, 4, 5, 6].

While there may be the odd individual for whom it does not work, the evidence shows that almost everyone benefits from substantial nootropic effects. Even the press is on board, with publications dubbing it “the first really effective smart medication” [7].

 

 

 

Modafinil Safety and Side Effects

Okay, that’s fantastic, but is Modafinil safe?

Without a doubt. Modafinil seems to be generally well-tolerated and safe, according to all available data. Indeed, University of Oxford experts claim that Modafinil is the first medicine for which there is strong evidence that it is both effective and safe [6, 7].

What are the adverse effects of Modafinil?

Modafinil users, on the other hand, often report minimal side effects [8]. What are the possible adverse effects? Here are a few of the most prevalent Modafinil adverse effects:

  • Sleeplessness. Modafinil, although not a stimulant, is an effective Wakefulness aid. Modafinil improves attention and productivity while impairing sleep. It also lasts quite a while. So, if you take it too close to bedtime, you can have difficulties sleeping.
  • Stomach problems When using Modafinil, some individuals develop nausea and diarrhea. This is the most unpleasant of the side effects in my opinion; it disrupts my digestive system. Even this may be handled by lowering sugar intake, increasing carbohydrate intake, and just remembering to eat (which is easy to overlook while you’re focused on your job).
  • Dehydration. Another effect of being preoccupied is that you may forget to drink water. However, it is critical to keep hydrated. You should be alright if you have a bottle of water beside you while working.
  • Headaches. I haven’t personally encountered any of these, although some modafinil users have reported headaches. Staying hydrated is crucial; if you do, your chances of getting a headache are reduced.
  • Sweating. Some folks experience perspiration while using this nootropic.

Modafinil is generally considered safe, but you should be informed of the possible negative effects.

None of these are really severe for the great majority of users, but they are all something to consider.

 

What exactly is Adrafinil?

Adrafinil [9], on the other hand, isn’t as well-known as Modafinil. Adrafinil, like many other smart medications, was created with Wakefulness, attention, and mood in mind.

Adrafinil was a pharmaceutical medication developed in France that was discontinued in 2011. Initially, the medication was developed as a replacement for Provigil. Since then, the smart pill has been sold as a nootropic over-the-counter.

Adrafinil has a chemical structure that is comparable to Modafinil [9]. There are, nevertheless, significant distinctions. The amide nitrogen of adrafinil bears an extra OH (hydroxyl group). Hydroxylamine is formed.

The medication is then transformed to Modafinil after it is eaten [10, 11]. The physiologically active element in Adrafinil is modafinil.

That is to say, it has comparable results:

  • Wakefulness
  • Concentration has improved.
  • Concentration has improved.
  • Productivity has increased.
  • Increased exhaustion

They are seldom as powerful as Modafinil, however. In fact, for prescription wakefulness purposes, physicians are increasingly skipping Adrafinil in favor of Modafinil [11].

 

 

 

Adrafinil Safety and Side Effects

So, is Adrafinil a safe drug? What are the possible adverse effects?

Yes, it is secure.

Even massive dosages (400mg per kilogram) failed to cause any harm in rats [10]. They have no idea what the deadly dosage is since it is so high [12].

One case study [13] had an individual who took 900mg per day for 10 months and experienced issues with his mouth muscles. Modafinil has been shown to produce similar effects (although seldom) [14]. These effects, however, were not long-lasting.

It’s also likely that Adrafinil is more difficult for your liver. Although I haven’t seen any study on this, several users claim that this is one of Adrafinil’s drawbacks.

Adrafinil is typically thought to be well tolerated.

What are the possible adverse effects?

They’re a lot like Modafinil. Here are some of the most prevalent Adrafinil adverse effects:

  • Sleeplessness. This is another chemical that promotes alertness. If you take it before going to bed, it will keep you awake [15].
  • Stomach problems Make sure you consume a balanced diet, with a focus on high-fiber foods.
  • Dehydration. While studying, drink plenty of water.
  • Headaches. Stay hydrated once more.

Remember to eat properly and remain hydrated while using Adrafinil or Modafinil. Also, take it first thing in the morning to avoid being up at night unless you’re pulling an all-nighter!

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Similarities between Adrafinil and Modafinil

Let’s look at the advantages and commonalities of these nootropics now that we’ve addressed the fundamentals and safety concerns.

Adrafinil and Modafinil were created for the same reason. As a result, a comparison of Adrafinil and Modafinil must start with their commonalities [16, 17].

The following are the effects of both of these nootropics:

  • Improved Cognition, Focus, & Productivity

When it comes to improving cognition, increasing attention, and eventually being more productive, both Modafinil and Adrafinil are quite beneficial. After all, they are clever medications!

When you take one of these nootropics, you’ll experience acute attention, which will help you increase your productivity or stay concentrated on whatever activity you’re working on. The largest advantages of any nootropic seem to be for CEOs, hustlers, and students.

  • Increasing Awakeness

Both of these nootropics are effective in keeping you up at night, whether you’re working late or just looking to pull an all-nighter due to online work or studies.

While Modafinil is a bit stronger, if you dose it correctly, you won’t be able to fall asleep after taking Adrafinil.

Both of these nootropics can help you remain awake and alert through hangovers or days with minimal sleep.

  • Smart Drugs That Are Safe

Both Adrafinil and Modafinil are reasonably safe medications. When using one of these smart medications, most people suffer minimal adverse effects.

When you should drink plenty of water and go to bed a bit later than normal while taking these nootropics, there is no significant risk.

Another significant advantage is that neither Modafinil nor Adrafinil have been demonstrated to be addictive or habit-forming [18, 19]. This is because they have no effect on the neural circuits linked to addiction [20].

As a result, you won’t feel compelled to use more and more. This is a significant bonus for those like myself who have addicted tendencies. It could even benefit those who are attempting to cut down on addictive activities like drinking [21] or gambling [22].

 

Differences Between Modafinil and Adrafinil

While the comparison of Adrafinil and Modafinil shows that these two smart medications have many similarities, I found them to be extremely different in terms of performance, dose, and other factors.

Here are a few major distinctions I discovered via my own research and experimentation:

  • Are they permissible?

Modafinil is a pharmacological medicine in most countries. That means you’ll need a doctor’s prescription to take it for one of the problems it’s approved for, such as sleep apnea or other sleep disorders. Possession may be theoretically unlawful depending on where you are.

Provigil, for example, is classified as a Schedule IV medication in the United States, which means it may only be imported by a qualified importer or someone who has a prescription. In order to utilize it lawfully in the United States, you’ll need a prescription.

Other nations, however, have distinct restrictions.

Adrafinil, on the other hand, is permitted to acquire over the counter without a prescription from a medical expert.

One of the most significant advantages is that Adrafinil falls into a significantly narrower legal gray area.

While purchasing Modafinil online is easy, it’s worth noting that Adrafinil is legal, which is a significant plus for consumers.

  • Effectiveness & Potency

There’s no denying it:

Adrafinil is much less effective and powerful than Modafinil. While the medicines are quite similar and are intended to provide the same advantages, Modafinil just outperforms them.

One would imagine that since Adrafinil turns to Modafinil within the body, the effects would be identical. Only a small portion of Adrafinil gets transformed to Modafinil. As a result, part of the Adrafinil is thrown away.

Adrafinil is not pure, but Modafinil is. To get the same effects as Modafinil, you’ll need a greater dose of Adrafinil.

  • Half-Life, Dosing, and Onset

You’ll need a lot of Adrafinil to get the same effects as Modafinil. Modafinil, for example, comes in 200mg doses. You’ll need 400-600mg of Adrafinil to have the same effect.

Adrafinil also takes around two hours to start working. Why? Because the medication takes around an hour to convert to Modafinil and another hour for the Modafinil to take effect.

Most Modafinil users, on the other hand, report that the effects begin to act approximately one hour after use. So keep it in mind as you prepare for your work session.

Adrafinil also has a shorter duration. Whereas Modafinil may last anywhere from 10 to 14 hours, Adrafinil only lasts approximately 8 to 10 hours. Occasionally, even less.

The half-life of Adrafinil may be really advantageous depending on your scenario. Modafinil may be the best option if you have a long day of work ahead of you.

If you’re just starting started in the afternoon, though, Adrafinil would be a better option. It may give you a productive day, but it will not keep you up at night. Modafinil makes this impossible.

  • Costs

Even when utilizing health insurance to purchase the prescription at a pharmacy, Provigil, one of the brand names for Modafinil, is prohibitively costly. You don’t have to purchase the brand name; generic Modafinil may be had for as little as Provigil, one of the brand names of Modafinil, is incredibly expensiveu2060—even when using health insurance to buy the drug at a pharmacy. Of course, you don’t need to buy the brand name; you can get generic Modafinil for as low as $0.89 per 200mg pill..89 per 200mg tablet.

However, for students or hustlers who use it often, this might get costly. We don’t all have limitless wealth at our disposal.

Adrafinil, on the other hand, may be purchased for as little as On the other hand, Adrafinil can be found for as low as $0.69 per serving. Now, to get similar effects as Modafinil, you’ll likely end up spending more on this nootropic. However, on a serving by serving basis, Adrafinil can be cheaper..69 per serving. To get the same results as Modafinil, you’ll have to spend more money on this nootropic. Adrafinil, on the other hand, may be less expensive per serving.

 

 

 

How to Make the Most of Nootropics

It should be emphasized that using smart medications on a regular basis is not recommended. It’s best to limit your Modafinil use to 1-3 times per week.

Adrafinil may be used instead of Modafinil. On days when you don’t take Modafinil, you may add Adrafinil to your weekly regimen. However, since Adrafinil turns to Modafinil in the body, it’s important to keep track of how much of this smart medicine you’re taking.

A weekly regimen of 1-2 Modafinil days and 1-2 Adrafinil days is manageable. You may also entirely switch to Adrafinil and utilize it 1-3 times each week.

You may also try a range of other clever medications that truly work to provide some variation. The spice of life is variety!

The best thing to do is experiment with different schedules and dosages to see what works best for you. Your body will quickly react and tell you what is and isn’t functioning.

 

What Nootropic Supplement Should You Purchase?

So, which should you purchase at the end of the day:

Adrafinil vs. Modafinil?

Modafinil is superior in every way.

Most individuals would benefit from this, particularly if they’ve previously experimented with nootropics.

However, Adrafinil may be appropriate for certain persons. Anyone in these scenarios, for example, could benefit from Adrafinil:

  • You’re new to nootropics and want to start with something a bit more mild.
  • You’ve checked the Country Guides and discovered that Modafinil is illegal in your country, and you don’t want to risk having your purchase seized.
  • You’re on a tight budget and need something more affordable.
  • You want something that will take effect quickly and can be taken later in the day.

Adrafinil could be a better option in certain situations.

However, most individuals will benefit more with Modafinil.

 

 

 

Adrafinil vs. Modafinil: Which Is Better?

Modafinil is much more effective and powerful in general.

Modafinil is the sole solution if you want to maximize your life and make the most of your smart drug day.

If you’re new to nootropics or simply want a few hours of strong concentration now and again, Adrafinil may help – without the bad side effects that Modafinil might bring if taken too late in the day.

Get your hands on the most potent smart medicine on the planet…Modafinil!

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References

  1. Ballon, J. S., & Feifel, D. (2006). A systematic review of modafinil: potential clinical uses and mechanisms of action. Journal of Clinical Psychiatry, 67(4), 554-566.

  2. Turner, D. C., Robbins, T. W., Clark, L., Aron, A. R., Dowson, J., & Sahakian, B. J. (2003). Cognitive enhancing effects of modafinil in healthy volunteers. Psychopharmacology, 165(3), 260-269.

  3. Gilleen, J., Michalopoulou, P. G., Reichenberg, A., Drake, R., Wykes, T., Lewis, S. W., & Kapur, S. (2014). Modafinil combined with cognitive training is associated with improved learning in healthy volunteers–a randomised controlled trial. European Neuropsychopharmacology, 24(4), 529-539.

  4. Baranski, J. V., Pigeau, R., Dinich, P., & Jacobs, I. (2004). Effects of modafinil on cognitive and metau2010cognitive performance. Human Psychopharmacology: Clinical and Experimental, 19(5), 323-332.

  5. A. D. Mohamed (2016). A randomized controlled experiment investigating the effects of modafinil on creative convergent and divergent thinking. 252-267 in The Journal of Creative Behavior.

  6. Battleday, R. M., & Brem, A. K. (2015). Modafinil for cognitive neuroenhancement in healthy non-sleep-deprived subjects: a systematic review. European Neuropsychopharmacology, 25(11), 1865-1881.

  7. H. Thomson (2015). Modafinil, a narcolepsy treatment, is the world’s first safe “smart drug.” The Guardian reports. https://www.theguardian.com/science/2015/aug/20/narcolepsy-medication-modafinil-worlds-first-safe-smart-drug
  8. WebMD (n.d.). Likelihood and Severity of Modafinil Side Effects https://www.webmd.com/drugs/2/drug-16962/modafinil-oral/details/list-sideeffects
  9. Pub Chem (2020). Adrafinil. https://pubchem.ncbi.nlm.nih.gov/compound/adrafinil#section=Depositor-Supplied-Synonyms
  10. Milgram, N. W., Callahan, H., & Siwak, C. (1999). Adrafinil: a novel vigilance promoting agent. CNS Drug Reviews, 5(3), 193-212.
  11. Patel, K. (n.d.). Examine.com: Adrafinil https://examine.com/supplements/adrafinil/
  12. Bastoji, H., & Jouvet, M. (1988). Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil. Progress in Neuro-psychopharmacology and Biological Psychiatry, 12(5), 695-700.
  13. Thobois, S., Xie, J., Mollion, H., Benatru, I., & Broussolle, E. (2004). Adrafinilu2010induced orofacial dyskinesia. Movement Disorders: Official Journal of the Movement Disorder Society, 19(8), 965-966.
  14. Maser, R. V., Liao, B., & Pandya, R. (2010). Modafinil-induced orofacial dyskinesia in an elderly patient with refractory bipolar depression. The Journal of neuropsychiatry and clinical neurosciences, 22(4), 451-e26.
  15. Baranski, J., & Pigeau, R. (1997). Selfu2010monitoring cognitive performance during sleep deprivation: effects of modafinil, du2010amphetamine and placebo. Journal of Sleep Research, 6(2), 84-91.
  16. RJ;, A;Dinis-Oliveira RJ; “Pharmacokinetic and Pharmacodynamic Aspects of MODAFINIL, a Cognitive Enhancer: Clinical and Forensic Aspects.” The date was March 14, 2021. https://pubmed.ncbi.nlm.nih.gov/31951804/.

  17. “Clinical Pharmacokinetic Profile of Modafinil,” ET;, Robertson P; Hellriegel. Pharmacokinetics in humans. National Library of Medicine, United States. The date was March 14, 2021. https://pubmed.ncbi.nlm.nih.gov/12537513/.

  18. Myrick, H., Malcolm, R., Taylor, B., & LaROWE, S. T. E. V. E. N. (2004). Modafinil: preclinical, clinical, and post-marketing surveillance—a review of abuse liability issues. Annals of Clinical Psychiatry, 16(2), 101-109.
  19. Jasinski, D. R., & Kovacevic-Ristanovic, R. (2000). Evaluation of the abuse liability of modafinil and other drugs for excessive daytime sleepiness associated with narcolepsy. Clinical Neuropharmacology, 23(3), 149-156.
  20. Patel, K. (n.d.). Examine.com/modafinil https://examine.com/supplements/modafinil/research/#neurology addiction
  21. Schmaal, L., Joos, L., Koeleman, M., Veltman, D. J., van den Brink, W., & Goudriaan, A. E. (2013). Effects of modafinil on neural correlates of response inhibition in alcohol-dependent patients. Biological Psychiatry, 73(3), 211-218.
  22. Zack, M., & Poulos, C. X. (2009). Effects of the atypical stimulant modafinil on a brief gambling episode in pathological gamblers with high vs. low impulsivity. Journal of Psychopharmacology, 23(6), 660-671.

 

 

Adrafinil is a stimulant that boosts alertness, motivation and concentration. It’s also known as “the smart drug” because it can be used to treat narcolepsy, ADHD and shift work sleep disorder. Modafinil is a wakefulness-promoting agent that has been approved for the treatment of excessive sleepiness associated with obstructive sleep apnea/hypopnea syndrome (OSAHS) in adults with no other contraindications. Reference: adrafinil reddit.

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Michael Walshinaldo