Alpha GPC u2013 Nootropics Expert
Nootropics expert, Dr. Nima Rezaei explains the health benefits of Alpha GPC and how it can help you reach your goals faster.
Alpha GPC is a nootropic supplement that was created by the company Nootropics Expert. It is designed to improve cognitive function and mood.
Alpha GPC has been demonstrated to help people age gracefully, increase memory and learning, and improve athletic performance.
Choline alfoscerate (L-Alpha Glycerylphosphorylcholine) is a choline source made from soy or sunflower lecithin. It’s also found in little levels in your body naturally.
For brain advantages, Alpha GPC is more bioavailable than other forms of choline. It quickly passes the blood-brain barrier, unlike choline citrate or choline bitartrate. As a result, experienced nootropic users choose Alpha GPC as a choline source.
Alpha GPC is a precursor of acetylcholine, an important neurotransmitter.
Alpha GPC aids in:
- Brain Power. Alpha GPC enhances mental vigor and improves mood. Choline supplementation may improve alertness and clarity of cognition.
- Neurotransmitters. Alpha GPC is recognized for its memory-enhancing properties. Its high bioavailability makes it an excellent source of choline for the production of acetylcholine, a neurotransmitter.
- Brain Enhancement. Alpha GPC encourages the growth of new brain cells. In addition, it helps your brain repair broken cell membranes.
Alpha GPC is a form of choline that your body produces in modest quantities. It’s also found in organ meats, dairy products, and wheat germ.
Choline is classified as an important nutrient since your body utilizes it quicker than it can generate it, necessitating choline supplementation from diet or a supplement.
Choline is required for the formation of acetylcholine, a neurotransmitter. Also, to make phosphatidylcholine (PC), which is utilized to make cell membranes.
Choline is so important to cognition and nerve function that humans couldn’t move, think, sleep, or remember anything without it.
Alpha GPC is found everywhere throughout your body. Even the generation of human growth hormone is aided by it. Athletes utilize it to improve their performance and gain lean muscle mass. It gives you additional energy throughout your exercise and helps you recover faster. I
We’re discussing how Alpha GPC influences your brain chemistry and wellness.
What’s the Difference Between Alpha GPC, CDP-Choline, and Choline Bitartrate?
Choline is a water-soluble substance with a structure similar to that of B vitamins. Choline is found as Alpha GPC, CDP-Choline, Choline Citrate, and Choline Bitartrate.
CDP-Choline (cytidine 5′-diphosphocholine) has only around 18% choline. Choline is spontaneously synthesized by your body into CDP-Choline (Citicoline). It’s subsequently transformed to phosphatidylcholine (PC), which helps make acetylcholine and aids cell membranes.
Choline Bitartrate is a cost-effective type of choline that contains roughly 40% choline by weight. Choline Bitartrate provides 400 mg of real choline per gram. It has a hard time crossing the blood-brain barrier. As a result, you won’t get the same nootropic effects as with Alpha GPC or CDP-Choline.
Alpha GPC contains around 40% choline by weight and passes the blood-brain barrier quickly. Alpha GPC is a naturally occurring byproduct of phosphatidylcholine in the brain (PC). When your brain requires more choline and the choline levels in your brain are low, PC is broken down from cell membranes. And it becomes Alpha GPC.
When you utilize Alpha GPC, your body and brain will thank you. Because it doesn’t have to eat its own cells in order to gain more choline.
What is the Function of Alpha GPC in the Brain?
In numerous ways, Alpha GPC improves brain health and function. But there are two that stick out.
- Acetylcholine, a neurotransmitter linked to memory and general brain function, is boosted by Alpha GPC. Alpha GPC is an acetylcholine precursor. Improving the effectiveness of neural transmission in your brain. Memory, learning, cognitive processing, and mental clarity all benefit from increased neuronal signaling.
In one research, 32 healthy participants were pretreated with either Alpha GPC or a placebo. They were given scopolamine ten days later to induce amnesia. The researchers discovered that Alpha GPC might counteract the effects of scopolamine on attention and memory. [ii]
Memory function in young healthy adults may be improved, according to these researchers. Simply by supplementing with Alpha GPC.
- The formation of cell membranes in the cerebral cortex is directly influenced by alpha GPC. The information processing center of your brain is the outer layer of neural tissues, sometimes known as “gray matter.” Intelligence, motor function, organization, personality, planning, and touch are all controlled by it. [iii]
Researchers performed a double-blind, placebo-controlled experiment with mild to moderate Alzheimer’s patients, which was published in Clinical Therapeutics. For 180 days, 400 mg capsules were taken three times a day. The results of this experiment demonstrated that dementia patients who were administered Alpha GPC improved consistently. [iv]
How do things go wrong?
Our brain chemistry and energy metabolism alter as we age.
Recall, response time, and mood all suffer.
The membranes of brain cells deteriorate.
Acetylcholine levels are decreasing[v].
The brain’s nerve growth factor decreases.
All of these age-related alterations have a role in aging-related neurodegenerative illnesses including Alzheimer’s and dementia.
Even if you don’t want to worry about the affects of aging, Alpha GPC may assist.
Advantages of Alpha GPC
Hundreds of research have shown that Alpha GPC will:
- Enhance your memory and learning abilities[vi].
- Restore acetylcholine bioavailability[vii]
- Nerve growth factor receptors in the brain should be restored and boosted[viii].
- Increase growth hormones in people of all ages[ix].
- Improve memory and cognitive skills in Alzheimer’s patients[x]
Alpha GPC is a water-soluble supplement that reaches your brain fast. It enhances signal transmission and preserves neurons once it reaches your brain.
By directly enhancing acetylcholine synthesis and release, Alpha GPC enhances brain function and learning processes. When your body tells you to.
This kind of choline is a metabolite of phosphatidylcholine (PC), not a precursor. This indicates that when PC has been digested and stripped of its fatty acids, just Alpha GPC remains.
Instead of scavenging Alpha GPC from your brain’s own membranes, you provide it with the precise form of choline it requires.
What is Alpha GPC’s current mood?
If you’re having difficulties waking up in the morning, combine coffee with 400 mg of Alpha GPC. Instead of your normal breakfast of high sugar, high carbohydrate,
Alpha GPC might help you feel more energized. Take it 45 minutes before exercising.
Memory, mood, mental performance, and vitality are all aided by Alpha GPC. Its capacity to nourish the acetylcholine in your brain cells should improve cognition in people of all ages and genders.
Clinical Trials on Alpha GPC
Researchers found that Alpha GPC had a favorable impact in increasing human growth hormone in one trial. [xi]
Dopamine Release is Boosted by Alpha GPC
Another experiment revealed an increase in dopamine release. [xii] This is especially relevant since it shows Alpha GPC may aid those with dopamine deficits. As well as reducing the symptoms of illnesses such as depression and Parkinson’s disease.
Learning and Memory are aided by Alpha GPC.
Alpha GPC seems to improve memory and concentration in a current study. This study suggests that combining Alpha GPC with donepezil improves its efficacy (acetylcholinesterase inhibitor). Much better than just taking donepezil.
Alpha GPC also improved learning and memory in rats. It improved brain energy systems while reducing age-related anatomical alterations. [xiii] [xiv]
Alpha GPC Relieves Alzheimer’s Disease Cognitive Impairment
In thirteen published clinical studies involving a total of 4,054 Alzheimer’s patients, Alpha GPC: [xv]
- Improved memory and concentration
- Stroke sufferers’ recovery is aided.
- Acute cerebrovascular illness symptoms were reversed.
- Is significantly more helpful in curing illness than choline or lecithin.
Dosage of Alpha GPC recommended
Alpha GPC contains around 40% choline by weight. As a result, 1,000 mg of Alpha GPC produces 400 mg of choline.
- The recommended dose of Alpha GPC for cognitive advantages is 400–1,200 mg per day.
- The recommended dosage of Alpha GPC for athletic training is 400 mg first thing in the morning and another 400 mg 15–30 minutes before working out.
- Alzheimer’s disease, dementia, and other cognitive problems may be treated with a daily dose of up to 1,200 mg.
Divide the daily Alpha GPC total into two or three pills each day for larger dosages. For example, 1,200 mg would be divided into 400 mg doses.
Side Effects of Alpha GPC
Your body produces Alpha GPC naturally. As a result, it is well-tolerated and safe.
Fatigue, headaches, nervousness, nausea, diarrhea, and gastrointestinal disorders are all possible side effects. This is usually a sign that your body has too much choline.
Avoid taking Alpha GPC in the evening since it gives many neurohackers an energy boost. You could also be having trouble sleeping.
A research published in 2021 found that those aged 50 and older who used Alpha GPC for at least 10 years had a 46 percent elevated risk of stroke. Alpha GPC is thus safe for short-term usage. However, if you require a choline supplement for a long time, CDP-Choline may be a better option (Citicoline).
What kind of Alpha GPC should you get?
Because Alpha GPC liquefies at 99-100 percent, several providers blend 50 percent Alpha GPC powder with 50 percent filler, such as silicon dioxide. Adjust your dose as needed.
Chemi Nutra, the U.S. commercial subsidiary of parent firm Chemi S.p.A., a privately owned pharmaceutical and nutraceutical company located in Milan, Italy, manufactures AlphaSize®, a proprietary version of Alpha GPC. In Italy and Brazil, they have cGMP-certified production facilities.
Soy or sunflower lecithin is used to make Alpha GPC. If you’re wanting to avoid soy, seek for A-GPC that says “no soy” or “made from sunflower lecithin.”
Expert Recommendation on Nootropics
400–1,200 mg of Alpha GPC each day
As a nootropic supplement, I suggest Alpha GPC.
Your body naturally produces some Alpha GPC. Also, the food you consume. However, studies have revealed that we do not acquire enough choline from dietary sources in our current diet.
Alpha GPC is very beneficial to those who are experiencing age-related cognitive deterioration. It has been shown in studies to help prevent or reverse cognitive impairments such as Alzheimer’s disease. Especially in the early and middle phases of the illness.
We recommend beginning with 400 mg each day. And Alpha GPC is an excellent addition to any racetam-family nootropic combination. Anything that increases your brain’s acetylcholine uptake to rise.
You must provide your brain with the choline it requires. Or it begins stealing acetylcholine from your own brain cells. Headaches are a sign that you’re deficient in choline.
Use a 1:4 ratio of Alpha GPC. 400 mg of Alpha GPC to 1,600 mg of a racetam like Piracetam, for example.
If you have age-related cognitive impairments like Alzheimer’s, you should increase your dosage to 1,200 mg per day.
“Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force output during, resistance exercise,” Ziegenfuss T., Landis J., Hofheins J. 20085(Suppl 1):P15 Journal of the International Society of Sports Nutrition (source)
“Effect of L-alpha-glyceryl-phosphorylcholine on amnesia produced by scopolamine,” Canal N., Franceschi M., Alberoni M., Castiglioni C., De Moliner P., Longoni A. 1991 Mar;29(3):103-7 in International Journal of Clinical Pharmacology, Therapy, and Toxicology. (source)
“Neurodegeneration from mitochondrial insufficiency: nutrition, stem cells, growth factors, and possibilities for brain rebuilding via integrative treatment,” Kidd P.M. Alternative Medicine Review 10(4):268-93, December 2005. (source)
De Jesus Moreno (iv) “Cognitive improvement in mild to moderate Alzheimer’s dementia after therapy with the cholinergic precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled experiment,” says Moreno. Clinical Therapeutics, 25(1), 178-93, 2003. (source)
[v] B.M. Cohen, P.F. Renshaw, A.L. Stoll, R.J. Wurtman, D. Yurgelun-Todd, S.M. Babb. “Decreased brain choline absorption in older individuals.” “Proton magnetic resonance spectroscopy in vivo.” JAMA 1995 Sep 20;274(11):902-7. (source)
“Behavioral effects of L-alpha-glycerylphosphorylcholine: impact on cognitive systems in the rat,” Drago F., Mauceri F., Nardo L., Valerio C., Lauria N., Rampello L., Guidi G. Feb 1992;41(2):445-8 in Pharmacology, Biochemistry, and Behavior. (source)
[vii] Bronzetti E., Felici L., and Amenta F., “Effect of ipsilateral nucleus basalis magnocellularis lesioning and L-alpha-glyceryl phosphorylcholine therapy on choline acetyltransferase and acetylcholinesterase in the rat fronto-parietal cortex.” 164(1-2):47-50 in Neuroscience Letters, December 24, 1993. (source)
“Nerve growth factor receptor immunoreactivity in the cerebellar cortex of elderly rats: impact of choline alfoscerate therapy,” Vega J.A., Cavallotti C., del Valle M.E., Mancini M., Amenta F. Mechanisms of Aging and Development, 69(1-2):119-27, 1993 Jun. (source)
“alpha-Glycerylphosphorylcholine treatment boosts the GH responses to GHRH of young and old participants,” say Ceda, Ceresini, Denti, Marzani, Piovani, Banchini, Tarditi, and Valenti. 1992 Mar;24(3):119-21 Hormone and Metabolic Research (source)
[x] “Multicentre investigation of l-alpha-glyceryl-phosphorylcholine versus ST200 among patients with probable senile dementia of Alzheimer’s type,” Parnetti L., Abate G., Bartorelli L., Cucinotta D., Cuzzupoli M., Maggioni M., Villardita C., Senin U. Drugs Aging, 3(2), 159-64, Mar-Apr 1993. (source)
“Effects of cytidine 5′-diphosphocholine injection on basal and growth hormone-releasing hormone-induced growth hormone production in older people,” Ceda G.P., Ceresini G., Denti L., Magnani D., Marchini L., Valenti G., Hoffman A.R. 1991;124(5):516-20 in Acta Endocrinologica (Copenhagen). (source)
“Changes in the interaction between CNS cholinergic and dopaminergic neurons generated by L-alpha-glycerylphosphorylcholine, a cholinomimetic medication,” Trabucchi M., Govoni S., Battaini F. Farmaco Sci.41(4):325-334, 1986 Apr. (source)
[xii] Traini E., Bramanti V., Amenta F. “Choline alphoscerate (alpha-glyceryl-phosphoryl-choline) is an ancient choline-containing phospholipid with an intriguing profile as a cognitive boosting drug.” Current Alzheimer’s Research 10(10):1070-9 (December 2013). (source)
“Prolonged treatment with -glycerylphosphorylethanolamine enhances the development of an active avoidance behavior and selectively boosts neuronal signal transduction in rats,” Florio T., Bajetto A., Thellung S., Arena S., Corsaro A., Bonavia R., Merlino M., Schettini G. Volume 11, Issue 5, pages 335-342 in Aging Clinical and Experimental Research, October 1999. (source)
[xv] “Choline alphoscerate in cognitive decline and acute cerebrovascular disease: an examination of published clinical data,” Parnetti L., Amenta F., Gallai V. Mechanisms of Ageing and Development, 122(16), 2041-2055, 2001. (source)
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Alpha GPC is a supplement that helps with cognition, brain function, and mood. It has been shown to help with the symptoms of ADHD, Alzheimer’s disease, and Parkinson’s disease. Reference: best alpha gpc supplement.
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