Armodafinil vs. Modafinil | Whatu2019s the Difference?

Armodafinil is a prescription medication. It’s the drug that many athletes use to help them perform better, and it’s right in more than one famous athlete’s locker room now.
What makes Armodafinil different from Modafinil? What do they each do? And what other benefits might they have for you or someone else you know? Find out by reading this article today.

Armodafinil vs. Modafinil is a question that has been asked by many people over the years. The “armodafinil vs modafinil reddit” is a place to learn more about the difference between these two drugs.

Armodafinil vs. Modafinil | What’s the Difference?

When it comes to the fight between Armodafinil and Modafinil, who comes out on top?

Although both smart medications have similar names, this does not necessarily imply that they have the same qualities.

However, the Differences between the two nootropics may be so little that one’s choice of nootropic is irrelevant.

As a result, we’re left with a lot of questions…

When it comes to efficacy, what are the distinctions between Modafinil and Armodafinil? Is one more durable than the other? What about the negative consequences of either?

Is there a major pricing difference when comparing Modafinil with Armodafinil? Or are we merely concerned about a difference of a few cents?

This comprehensive guide was designed with one goal in mind: to address all of those questions:

You’ll know all there is to know about the Modafinil vs. Armodafinil: Which is Better? controversy after you’ve finished reading. Which nootropic is the best for you to take?

 

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What Does Modafinil Mean?

Most people are familiar with Modafinil, but in case this is your first time hearing about it, we’ll give you a quick primer.

Modafinil is a Schedule IV prescription medicine that was produced by Cephalon until Teva Pharmaceuticals bought them out. Modafinil was licensed by the US Food and Drug Administration (FDA) in 1998 for the treatment of excessive daytime drowsiness in the following disorders [1]:

  • Narcolepsy
  • Obstructive sleep apnea (OSA) is a kind of sleep apn
  • Sleep disturbances caused by shift work

Modafinil has helped millions of sleep-deprived individuals in improving their quality of life and allowing them to operate throughout the day without feeling tired.

Modafinil, on the other hand, is more known for its off-label usage as a cognitive enhancer. After many years of individuals in high-performance occupations (students, entrepreneurs, CEOs, doctors, etc.) utilizing the medication in this way, scientists have begun to look into it more [2]:

“In human patients that were artificially sleep deprived, clinical trials have also demonstrated favorable benefits of [Modafinil] on cognitive function.”

“…[Modafinil] seems to improve cognitive function in sleep-deprived healthy individuals.”

“There has also been evidence of improved working memory, impulse control, alertness, and sustained attention in healthy volunteers.”

Modafinil is classed as a “eugeroic” since its major function is to promote wakefulness and alertness.

However, we must properly present the opposite side in the Modafinil vs. Armodafinil: Which is Better? conflict…

 

What Is Armodafinil and How Does It Work?

Armodafinil, like Modafinil, is a non-narcotic prescription medicine classified as Schedule IV that was developed by Cephalon. The FDA authorized it under the brand name “Nuvigil” in 2007 to treat the same issue as Modafinil and for the same three medical conditions [3].

Armodafinil is the R-(-)-enantiomer of Modafinil, which is a racemic molecule with two enantiomers: R-(-)-enantiomer and S-(+)-enantiomer.

Cephalon’s Modafinil patent lapsed in 2015, meaning they no longer have exclusive rights to produce and sell the medicine. As a result, Cephalon required a new medicine to stay profitable. They also didn’t want to lose their monopoly on the sleep-deprived populace [4].

The R-(-)-enantiomer of Modafinil was revealed to have the same qualities as Modafinil after extensive testing.

Except it lasts far longer in your system and is said to be more effective by some. To preserve market supremacy in the pharmaceutical sector, this is a frequent strategy [5]:

“Chiral switching” – the replacement of a racemic medicine in the market with a single enantiomer — “may give an advantage in sustaining a high market share even in the face of generic competition.”

Armodafinil has also been researched for its fatigue-reducing properties, and some studies suggest that this Modafinil offshoot has a lot of potential [6].

So, what does this signify for the struggle between Provigil and Nuvigil? Is there no difference in the effects of each drug?

 

 

 

Modafinil vs. Armodafinil: Which is Better?

Whether you want to compare Nuvigil vs. Provigil, or Modafinil vs. Armodafinil: Which is Better?, it really doesn’t matter.

There are many more parallels than Differences between the two medicines. The distinctions are mostly significant to experienced smart drug users, such as ourselves, who want to improve their cognitive enhancement.

 

Similarities

When you compare Provigil with Nuvigil, you’ll see that they’re very similar. In fact, you’ll have a considerably harder time distinguishing between the two prescription drugs.

  • Pharmacological Mechanisms of Action are the same.

The actual mechanism of action for enhancing alertness in Modafinil vs. Armodafinil is still unclear to this day.

Both central nervous system (CNS) stimulants, however, seem to function in the same way. They target specific areas of the brain rather than engaging the whole brain [7]:

“By binding to the dopamine transporter and raising dopamine concentrations in certain brain areas, both armodafinil and modafinil prevent dopamine reuptake. Modafinil is not blocked by dopamine receptor antagonists (e.g., haloperidol) or dopamine synthesis inhibitors (e.g., a-methyl-p-tyrosine).”

It’s worth emphasizing that, unlike amphetamines and other conventional stimulants, Armodafinil and Modafinil have a very minimal potential for addiction and misuse.

  • Food Intake Influences

While taking Modafinil or Armodafinil with meals would likely delay the beginning of its effects by 1-2 hours, the total bioavailability of both medications will not be affected [8, 9].

In other words, when it comes to Modafinil vs. Armodafinil: Which is Better?, you can expect the effects to “kick in” quicker when you take either smart drug without food.

  • Identical Terminal Half-Life

The half-life of a medication is the amount of time it takes for its concentration in the body to drop by half. The terminal half-life of Armodafinil and Modafinil is approximately the same at 13-15 hours [10]:

“Despite having comparable half-lives, armodafinil plasma concentrations are greater late in the day than modafinil plasma concentrations on a milligram-to-milligram basis.”

When compared to modafinil, armodafinil’s pharmacokinetic profile may result in better alertness throughout the day in individuals with ES.”

Later in the “Differences” section, we’ll build on this discovery.

  • Treatment Efficiency for Prescribed Conditions

When it comes to treating the disorders for which they were prescribed, there is no rivalry between Modafinil and Armodafinil.

A randomized double-blind clinical trial conducted across multiple centers in 2011 found they were equally effective in reducing excessive sleepiness brought about by Sleep disturbances caused by shift work [11]:

“Both modafinil and armodafinil significantly improved sleepiness mean grades as compared to baseline (P < .0001). Responder rates with armodafinil (72.12%) and modafinil (74.29%) were comparable (P = .76). Adverse event incidences were comparable.

…There was no difference in effectiveness or safety between armodafinil 150 mg and modafinil 200 mg in the trial.”

A 2016 meta-analysis involving the use of either Modafinil or Armodafinil also demonstrated equal effectiveness of both drugs in reducing daytime sleepiness within patients diagnosed with Obstructive sleep apnea (OSA) is a kind of sleep apn [12].

Both medications were obviously effective, had little adverse effects, and were well tolerated by patients.

  • Boosted Focus, Cognition, & Productivity

Finally, Armodafinil and Modafinil seem to have similar cognitive-enhancing effects. The following are the most prevalent side effects observed by a large number of test participants [13]:

  • Short-term memory has improved.
  • Increased concentration
  • Increased self-assurance (i.e. more motivated)
  • Alertness levels that are higher
  • Longer concentration span

The only real competition in the Modafinil vs. Armodafinil: Which is Better? discussion is which smart drug provides more of these effects, and which drug lasts longer. This tends to be very subjective and entirely dependent on the individual user.

 

Differences

This is where the Nuvigil vs. Provigil discussion becomes intriguing, as fans will debate the differences between the two for hours.

However, as you’ll see below, the distinctions between Modafinil and Armodafinil are minor in quantity and scope.

  • Chemical Composition

Modafinil is a “racemic” blend of two distinct substances [14], as previously noted.

 

 

The “enantiomers” of R-(-)-modafinil and S-(+)-modafinil are R-(-)-modafinil and S-(+)-modafinil They have the same atoms and the same 3D structure, but in the third dimension, they are non-superimposable mirror reflections of each other.

Here’s what we mean in plain English: Your hands are diametrically opposed. Even though their structures are virtually similar, you cannot have the same ‘hand’ if you lay your left hand on top of your right.

Both enantiomers of modafinil are present. The “R” enantiomer is the only one that exists in armodafinil. This is why it’s known as a “enantiopure” chemical (and why “Armodafinil” is pronounced “R-Modafinil.”)

While there may not seem to be a significant difference, these two enantiomers interact with your body’s enzymes in comparable but distinct ways.

  • Properties of Pharmacokinetics

Remember that article we mentioned before that said Armodafinil might help you stay awake longer?

That’s where the debate between Provigil and Nuvigil becomes fascinating.

The characteristics of both enantiomers of Modafinil are substantially distinct from one another:

  • The half-life of the R-enantiomer is 10-14 hours, whereas the S-enantiomer is 3-4 hours [15].
  • The S-enantiomer is three times shorter in duration than the R-enantiomer and is removed three times quicker [16].
  • The R-enantiomer binds to the dopamine transporter three times better than the S-enantiomer, making it three times more efficient in inhibiting dopamine uptake [14].

Furthermore, the R-enantiomer is physiologically active (that is, it has effects), while the S-enantiomer is biologically inactive.

This does not, however, contradict what we previously said regarding the half-life of both medications. While Modafinil and Armodafinil have almost identical effective half-lives, the enantiomers have drastically varied half-lives.

Armodafinil also has a longer-lasting impact since it remains in your body for a longer amount of time. Some researches believe Armodafinil has a greater wakefulness impact than Modafinil [17]:

“When compared to modafinil 200mg, armodafinil 200mg demonstrated a similar peak plasma concentration with greater concentrations 6-14 hours post-drug, as well as better wakefulness and maintained attention for a longer duration.”

Keep in mind that a greater dosage of Armodafinil was utilized, since 200mg of Modafinil is comparable to 150mg of Armodafinil.

  • Dosing Schedule

The optimal Modafinil dose differs from the ideal Armodafinil dosage.

However, the recommended dosage to take for cognitive improvement from either medicine is the same as it is for their specified conditions:

For Provigil (i.e., Modafinil), 200mg once a day in the morning is the recommended dose for Obstructive sleep apnea (OSA) is a kind of sleep apn and Narcolepsy. It comes in tablets of 100mg or 200mg.

For Nuvigil (i.e., Armodafinil), it’s 150mg once a day in the morning for Obstructive sleep apnea (OSA) is a kind of sleep apn and Narcolepsy. It comes in tablets of 50mg, 150mg, 200mg, or 250mg.

With both drugs, the corresponding dose is simply taken one hour before a work shift if the condition being treated is Sleep disturbances caused by shift work.

While the highest daily dosages of Armodafinil (250 mg) and Modafinil (400 mg) are well tolerated, no further advantages above the authorized levels have been shown [18].

 

Safety Concerns and Side Effects

Modafinil vs. Armodafinil: Which is Better? — which one is safer to take and comes with a lower frequency, and severity, of side effects? It turns out that both are virtually the same when it comes to safety [19]:

“…modafinil and armodafinil were effective and well tolerated by pediatric patients [<18 years old] with Narcolepsy over a long period of clinical follow ups (up to 10 years). Concomitant administration of other psychopharmacological agents did not result in any significant side effects.

The use of modafinil and armodafinil increased the capacity of patients to remain awake and did not worsen pre-existing mental disorders.”

They also seem to have a similar profile of adverse effects [20]:

“Adverse events reported were mild to severe in severity. Headache (29 percent and 2%, respectively) was the most often reported adverse event when using armodafinil or modafinil, followed by diarrhea (12 percent and 5%), nausea (10 percent and 2%), and dizziness (10 percent and 5%).”

Individuality and biochemical uniqueness will determine if Modafinil causes more side effects (in terms of severity and frequency) than Armodafinil (and vice versa).

Both Armodafinil and Modafinil have a variety of contraindications that you should be aware of [21]:

Due to their stimulant qualities, these medicines may impair the efficacy of blood pressure medications (such as propranolol), since they slightly raise blood pressure.

Both medicines will interact with hormonal contraceptives and reduce their effectiveness, necessitating the use of alternate birth control methods. They’re “Category C” medications, which implies they might harm the fetus’ development in pregnant women [22].

Both medicines increase CYP3A4 activity while decreasing CYP2C19 activity. The concentrations of any pharmaceuticals metabolized by these liver enzymes will be lowered or elevated (respectively), thus check the product monographs for any co-administered medications [23, 24].

Before using any prescription medicine, please consult your doctor about any pre-existing conditions you may have (such as cardiovascular concerns, mental health history, or a defective liver or kidney).

 

Modafinil vs. Armodafinil: Which is Better? | Cost Comparison

You’ll be surprised at how much Provigil and Nuvigil cost when you compare the two.

According to Drugs.com, the following is what you may anticipate to spend if you buy either medicine without insurance from a real pharmacy [25, 26]:

  • Provigil 200mg costs US$24.64 a pill. The cost of generic Modafinil has been reduced to US$10.86 per tablet.
  • The price of 150mg Nuvigil increases to $29.79 a pill. Paying $6.88 a pill for generic Armodafinil will save you a lot of money.

Buying the generic version of these nootropics from a reliable and genuine online Modafinil retailer like Buy Moda is, in our view, the best option.

When it comes to generic versions, we recommend Modalert for Modafinil and Waklert for Armodafinil. Both types are made by SUN Pharmaceuticals and, in our view, are the highest-quality generics on the market.

You may get Waklert 150 mg or Modalert 200 mg for as cheap as For either 150mg Waklert or 200mg Modalert, you’ll pay as little as $0.89-2.30 per pill. The larger your order, the less you end up paying per pill [27]..89-2.30 per tablet. The more pills you purchase, the less you spend per pill [27].

The price difference between buying Armodafinil online and buying Modafinil online, as we advocate, is extremely little.

As you’ll see in the next section, your preference between Modafinil vs. Armodafinil: Which is Better? really comes down to your subjective response.

 

Which Nootropic Is More Effective?

Armodafinil vs Modafinil… There seems to be little difference between the two smart medications.

This is the phase of the discussion when anecdotal evidence and reader reports play a big role.

Based on all of our suggestions so far, here’s what we’d tell readers who are still undecided about Provigil vs. Nuvigil:

We recommend obtaining a sampling pack from your preferred online Modafinil retailer because to its comparable pharmacological and safety characteristics.

Both Armodafinil and Modafinil will last around two weeks. This will give you plenty of opportunity to assess your reaction to both.

You’ll be able to monitor how they effect your sleep with the help of your supervising physician (i.e., how easily you fall asleep, how easily you wake up, and capacity for sleep interruption). But, more crucially, you’ll be able to evaluate the daily cognitive benefits each gives.

While consumers may respond differently to Armodafinil or Modafinil, reports seem to be quite consistent:

Modafinil has a shorter half-life and operates more quickly, but it strikes you “harder.” Modafinil may even give you a “feel-good” high. We take it no later than 10 a.m., or no later than noon if we wish to minimize sleep disruption.

Armodafinil produces a “cleaner” and “smoother” improvement in attention that lasts longer but isn’t as noticeable. Some users claim to have less jitters and are less distracted. As a result, we usually take it 1-2 hours sooner than Modafinil.

We would never take either nootropic on a daily basis for cognitive improvement, regardless of the nootropic. Only people with medical disorders for whom Modafinil or Armodafinil is recommended should take it on a daily basis.

In more concrete words, we avoid taking more than 2-3 doses of Modafinil or Armodafinil each week. Users have reported effectively staying with one or the other, as well as rotating between the two.

 

 

Modafinil vs. Armodafinil: Which is Better? | The Verdict

So what can we conclude from this Modafinil vs. Armodafinil: Which is Better? side-by-side comparison?

There is no clear victor in this case, since both Modafinil and Armodafinil successfully accomplish their goals and have much more similarities than differences.

Both smart medications are expected to provide significant cognitive improvements with few to no negative effects.

The only significant distinction between the two is how you react to them. Modafinil tends to deliver a greater but shorter-lasting cognitive boost, whilst Armodafinil provides a somewhat weaker but longer-lasting cognitive increase. 

However, you are not required to use one over the other: Continue to educate yourself in order to get the greatest smart medicine option for you!

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References

  1. A review of modafinil: its features, function, and usage in critical care, Hashemian SM, Farhadi T. 2020;9(1):82-86. doi:10.1080/21556660.2020.1745209.
  2. M. Mereu, A. Bonci, A. H. Newman, and G. Tanda. The neuroscience of modafinil as a cognitive enhancer and possible therapy for drug abuse problems. 415-434 in Psychopharmacology (Berl). doi:10.1007/s00213-013-3232-4.
  3. Armodafinil for severe daytime drowsiness, Nishino S, Okuro M. 2008;44(6):395-414. doi:10.1358/dot.2008.44.6.1195861.

  4. PROVIGIL Drug Information. drugpatentwatch.com (accessed June 13, 2020).
  5. Patent cliff mitigation strategies: reviving blockbusters, A. Kakkar. 2015;25(12):1353-1359. doi:10.1517/13543776.2015.1088833.

  6. Effect of armodafinil on cognition in HIV/AIDS patients with tiredness, McElhiney M, Rabkin J, Van Gorp W, Rabkin R. 2013;35(7):718-727 in J Clin Exp Neuropsychol. doi:10.1080/13803395.2013.823910
  7. Chapter 28 – To Market, To Market – 2008, Hegde S, Schmidt M. Annu Rep Med Chem. 2009;44:577-632. doi:10.1016/S0065-7743(09)04428-5
  8. [C-IV] PROVIGIL® (modafinil) Tablets The date is June 12, 2020. accessdata.fda.gov
  9. Expert Opin Pharmacother. 2010;11(6):993-1002. doi:10.1517/14656561003705738. Bogan RK. Armodafinil in the treatment of excessive drowsiness. Expert Opin Pharmacother. 2010;11(6):993-1002.
  10. M Darwish, M Kirby, ET Hellriegel, P Jr Robertson Despite having the identical terminal half-lives, armodafinil and modafinil exhibit significantly distinct pharmacokinetic profiles, according to data from three randomized, single-dose pharmacokinetic trials. 2009;29(9):613-623 in Clin Drug Investig. doi:10.2165/11315280-000000000-00000

  11. Tembe DV, Dhavale A, Desai H, et al. Armodafinil versus Modafinil in Patients of Excessive Sleepiness Associated with Sleep disturbances caused by shift work: A Randomized Double Blind Multicentric Clinical Trial. Neurol Res Int. 2011;2011:514351. doi:10.1155/2011/514351
  12. Kuan YC, Wu D, Huang KW, et al. Effects of Modafinil and Armodafinil in Patients With Obstructive sleep apnea (OSA) is a kind of sleep apn: A Meta-analysis of Randomized Controlled Trials. Clin Ther. 2016;38(4):874-888. doi:10.1016/j.clinthera.2016.02.004

  13. Modafinil. The date is June 15, 2020. drugsand.me
  14. R-modafinil (armodafinil): a novel dopamine uptake inhibitor and prospective medicine for psychostimulant misuse, Loland CJ, Mereu M, Okunola OM, et al. 72(5):405-413 in Biol Psychiatry. doi:10.1016/j.biopsych.2012.03.022
  15. Primary Hypersomnia Treatment & Management. Retrieved June 14, 2020. emedicine.medscape.com
  16. Modafinil formulations and procedures for rapid onset and short-term usage. patents.google.com (accessed June 13, 2020).
  17. DF Dinges, S Arora, M Darwish, and GE Niebler. Single dosages of armodafinil had pharmacodynamic effects on alertness in healthy people during a nocturnal period of acute sleep deprivation. 159-167 in Curr Med Res Opin, 2006. doi:10.1185/030079906X80378

  18. Prior Authorization with Quantity Limit Criteria Program Summary for Nuvigil®/armodafinil and Provigil®/modafinil. providers.bcbsal.org (accessed June 16, 2020).

  19. 0954 LONG-TERM USE OF MODAFINIL AND ARMODAFINIL IN PEDIATRIC PATIENTS WITH NARCOLEPSY. Ivanenko A, Kek L, Grosrenaud J. 10.1093/sleepj/zsx050.953. Sleep. 2017;40(suppl 1, 28):A354–A355.

  20. Darwish M, Kirby M, D’Andrea DM, Yang R, Hellriegel ET, Robertson P Jr. Pharmacokinetics of armodafinil and modafinil after single and multiple doses in patients with excessive sleepiness associated with treated Obstructive sleep apnea (OSA) is a kind of sleep apn: a randomized, open-label, crossover study. Clin Ther. 2010;32(12):2074-2087. doi:10.1016/j.clinthera.2010.11.009

  21. PROVIGIL VS NUVIGIL rxlist.com, retrieved 17 June 2020.
  22. Birth Defects from Provigil. birthinjuryguide.org (accessed June 13, 2020).
  23. A. Rowland, M. van Dyk, D. Warncken, A. A. Mangoni, M. J. Sorich, A. Rowland. A model-informed cocktail reaction phenotyping experiment strategy was used to assess modafinil as a perpetrator of metabolic drug-drug interactions. 84(3):501-509 in Br J Clin Pharmacol. doi:10.1111/bcp.13478
  24. M Darwish, M Kirby, P Jr Robertson, ET Hellriegel. In healthy persons, the interaction profile of armodafinil with medicines processed by the cytochrome P450 enzymes 1A2, 3A4, and 2C19. doi:10.2165/00003088-200847010-00006 Clin Pharmacokinet. 2008;47(1):61-74.

  25. Modafinil and Provigil are being compared. drugs.com, retrieved on June 16, 2020
  26. Armodafinil and Nuvigil are being compared. drugs.com, retrieved on June 16, 2020
  27. Modafinil [Provigil] may be purchased online at BuyModa Generics. buymoda.org (accessed June 17, 2020).

 

 

Armodafinil is a medication that is prescribed to patients suffering from narcolepsy, obstructive sleep apnea, and shift work disorder. Modafinil is an amphetamine-based medication that is also prescribed for similar conditions. The two medications have some similarities but are different in many ways. Reference: armodafinil vs adderall.

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