DMAE – Supplement Benefits, Dosage, Side Effects

DMAE, or dimethylaminoethanol is a naturally occurring chemical that has been used in supplement form for many years. It can increase brain cell regeneration and improve memory by helping with the formation of new neurons. DMAE supplements are marketed as being able to make cognitive functions more efficient but few side effects have been reported so far – mostly just mild skin rashes at higher doses.

DMAE is a supplement that has been used for many years to improve memory, mood and cognitive function. Its benefits are well documented and it has few side effects. The recommended dosage of DMAE is 500mg per day.

DMAE - Supplement Benefits, Dosage, Side Effects

An Overview of DMAE

Many skincare products use DMAE as a Supplement.

In the human brain, DMAE (dimethylaminoethanol) is a naturally occurring amine. It may affect choline and perhaps the neurotransmitter acetylcholine, according to researchers.

Because of its cholinergic properties, it may have nootropic advantages for:

In principle, DMAE, like other cholinergic drugs, might be utilized to improve learning and memory.

However, there is little evidence to support this argument.

Despite this, many nootropics users report that this pill works well for them.

DMAE as a Supplement

For years, DMAE has been employed in cognitive and mood-enhancing goods, as well as beauty items.

Some fish, notably anchovies, contain it naturally.

The most common type of DMAE on the market is DMAE bitartrate.

What is the Function of DMAE?

Many neuropsychological disorders might benefit from DMAE therapy.


According to research, DMAE may be beneficial in the treatment of ADHD symptoms, particularly in younger persons.

There is some evidence that DMAE may help people with ADHD symptoms.

For decades, Deanol was the brand name for DMAE, which was used to treat mood and concentration issues.

In recent decades, it has fallen out of favor as a prescription drug.

That isn’t to say it is unsuccessful; it simply means that research has dried up.

This supplement has had beneficial benefits for certain people.

The majority of the studies supporting this usage were conducted in the 1970s, before ADHD was even a recognized diagnosis. As a result, they might be obsolete.

ADHD DMAE Research

Children with learning and hyperactivity issues were administered deanol, methylphenidate (Ritalin), or placebo for three months in a 1975 research.

When compared to placebo, Deanol looked to be roughly as effective as methylphenidate in reducing symptoms.

“There is sufficient evidence for an impact of deanol in the literature to encourage additional exploration,” the researchers write.

Young healthy guys who took DMAE for 2-3 weeks enhanced their attentiveness, sleep habits, and muscular tone, according to another research.

According to one animal research, DMAE might be utilized to treat learning and behavior disorders as well as hyperkinetic behavior.

Young healthy guys who took DMAE for 2-3 weeks enhanced their attentiveness, sleep habits, and muscular tone, according to another research.

For Mood DMAE

Limited data suggests that DMAE may increase mood and feelings of well-being.

Although this impact has not been fully investigated, many users claim beneficial results.

One clinical investigation suggests that DMAE may lower theta and alpha brain waves. Increased alertness and focus are linked to decreases in certain brain wave frequencies.

Researchers discovered that those who took DMAE “felt better and were more active.” They reported higher levels of happiness and demonstrated enhanced brain activity during EEG tests.

These are preliminary results, and additional study is required.

They do, however, suggest that DMAE might be beneficial for enhancing mood.

Epilepsy and DMAE

In human temporal lobe epilepsy patients and rat hippocampus tissue, a 2019 research “clearly revealed an antiepileptic effect of DMEA.”

Alzheimer’s and Dementia DMAE

There’s some evidence that DMAE may help you age gracefully.

The evidence concerning DMAE and Alzheimer’s disease is conflicting.

In one trial, 14 senile outpatients were administered DMAE for four weeks. It resulted with favorable outcomes.

Researchers observed no substantial improvement from utilizing DMAE in another investigation of 27 people with Alzheimer’s disease.

In fact, they observed unfavorable side effects in a few of subjects.

Schizophrenia and DMAE

Researchers also discovered that DMAE may assist with certain schizophrenia symptoms.

After using DMAE, schizophrenic individuals demonstrated enhanced motor and verbal activity in one research. According to the researchers, the gains might take up to 6 months to completely take effect.

Neuroprotection with DMAE

DMAE may have neuroprotective, lifespan, and anti-aging properties.

In one research, DMAE greatly enhanced the life of elderly mice.

This might be attributed to changes in cell membranes as a result of aging. Choline is required for cell membrane production, and DMAE provides a precursor to choline while also suppressing choline metabolism.

The capacity of DMAE to scavenge free radicals is another possibility for its anti-aging benefits.

According to certain studies, DMAE goes out and eliminates free radicals that are responsible for cell mutation.

However, no difference in anti-cancer characteristics or lifespan was found between DMAE-treated and placebo-treated female mice in this animal investigation.

As a result, the effectiveness of DMAE is debatable. More research is required, particularly on people.

The Effects Of DMAE On The Brain

DMAE works by boosting the flow of acetylcholine in the brain.

According to some sources, DMAE is an acetylcholine (ACh) precursor. Clinical evidence, on the other hand, suggests that this is not the case.

DMAE may indirectly boost acetylcholine by promoting choline synthesis, however the data is still mixed.

DMEA is not methylated to choline, according to one research, and so has no effect on brain ACh levels.

It did, however, raise choline levels in the brain.

When choline production is limited or when choline consumption for acetylcholine synthesis is impeded, it may be therapeutically beneficial.

Despite its cholinergic qualities, it is still unclear how DMAE boosts choline levels in the brain and plasma, according to another investigation.

It’s conceivable that it will drive neurons to spontaneously produce choline. Alternatively, it might slow down the breakdown of acetylcholine.

In each case, there is insufficient proof.

Finally, how precisely DMAE impacts the cholinergic system is yet unknown. If you want to raise ACh in a direct way, you should definitely try a different nootropic.

Anti-Inflammatory Properties of DMAE

DMAE works as an antioxidant and anti-inflammatory, removing free radicals from your cells.

How Much DMAE Do I Need?

The average DMAE nootropic dosage is 100-250 mg per day.

Potential Side Effects of DMAE

The body produces DMAE as a natural chemical. When used at the proper dosage, it is nontoxic and should not cause any adverse effects.

For further impact, many individuals use it with a choline source. According to some anecdotal findings, choline and DMAE have a synergistic impact.

When used in excessive amounts, some persons have reported:

  • Headache
  • Insomnia
  • Muscle ache

In big dosages, DMAE reduced the seizure threshold in rats and mice, so be cautious if you have seizures.

Reddit DMAE Reviews

For whatever reason, DMAE has shown to be more effective and less free of side effects than typical stimulants, and unlike modafinil, it seems to be quite free of side effects beyond the first few days. u200bu/Neuropharma

I’ve only been taking it for a few days, but I’m really enjoying it. I was on 100 mg of Modafinil at the time, and it really enhanced my experience. I felt as though I had taken 200 milligrams of Modafinil. So, tomorrow, I’m simply going to take the DMAE and see how it affects me. I’ve spent my whole life looking for help with ADD. My mother would never allow me to take medicine since I underwent heart surgery when I was born. u200bWIN2014

This is one of my favorites. I’d want to add something to my stack to help me recall my dreams better, but this has greatly improved my sleep. Anonymous

Amazon Reviews for DMAE

I’ve been seeing it for a while now: I’ve been waking up tired and feeling tired all day. I suppose one way to describe it is brain fog. When I tested DMAE on its own, it looked to function well, and the fog dissipated within six hours. I wasn’t even taking anything extra to aid my memory recall. Akokisa

This is fantastic. It’s been quite beneficial to my mental health. Let me tell you, I don’t misplace my keys very much these days… It takes a little while to get going, but once it does, it’s fantastic. It’s as though the fog has dissipated. Because this substance had such an influence on me, I stopped taking L-tyrosine for a period (I started on it again though and now my mood and energy are back up and my brain is cranked too). Tyrosine and DMAE seem to be a good match. Dakota

It has substantial anti-aging benefits as well as mental clarity and vigor. Strongly recommended! billybangdouglas

Final Thoughts

Do you have any queries concerning DMAE supplementation? Do you have any DMAE supplementation experience? Please let us know what you think in the comments section below.

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DMAE is a supplement that has been banned in the US for being unsafe. DMAE is a fat-soluble antioxidant and it is often used as a treatment for brain injuries, Alzheimer’s disease, and other conditions. Reference: dmae bitartrate banned.

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Michael Walshinaldo