Modafinil and Weight Loss | A-Z Guide

Providing you with the best information, we introduce you to a drug that is gaining popularity because of its ability to help people lose weight. This A-Z guide will tell you everything there is to know about modafinil and how it works in your body.

Modafinil and weight loss is a topic that has been in the news lately. This article provides an A-Z guide to the subject. Read more in detail here: modafinil and weight loss reddit.

Modafinil and Weight Loss | A-Z Guide

Is there a link between Modafinil and weight reduction that has been scientifically proven?

Is Modafinil a “magic diet medication” that can help you lose weight quickly and easily?

After reading countless anecdotal tales from Modafinil users on the Internet [1], you may have asked yourself these questions.

Modafinil is said to provide a variety of cognitive effects, including enhanced attention, increased energy, and prolonged concentration for many hours.

For all three objectives, the smart medicine has regularly demonstrated to be successful. However, there is little information available on taking Modafinil to lose weight.

Furthermore, there is no clear difference drawn between “weight loss” and “fat loss,” since it is completely feasible to lose weight without achieving a desired shift in body composition – for most individuals, this would mean the reduction of body fat.

We created this thorough guide to assist anybody who searches Google for “Modafinil weight loss” but is unable to find a good response.

 

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What exactly is Modafinil?

Here is some introductory background material for those who are unfamiliar with Modafinil or how it exerts its cognition-boosting benefits.

Modafinil is classified as a “eugeroic,” which is another term for a wakefulness-promoting substance. It was approved by the Food and Drug Administration in 1998 for treating excessive drowsiness associated with narcolepsy under the brand name “Provigil.”

Modafinil was subsequently proven to be effective in treating drowsiness associated with various medical problems such as sleep apnea, shift work sleep disorder, and insomnia [2]. Because of its capacity to block the human body’s natural urge for sleep, it was hailed as a strong drug.

Although Modafinil was designed to help patients with sleep issues, a few healthy people began experimenting with it off-label to see whether it may help them with their cognitive abilities. The prescription medicine turned out to be a powerful smart drug for improving mental qualities linked to productivity, much to their surprise.

Long-term Modafinil users report the following advantages:

  • Improved information processing and memory
  • A heightened degree of concentration that may last for many hours
  • Significant fatigue reduction
  • Unprecedented increases in self-sustaining motivation

Individuals in occupations and sectors where extraordinary levels of productivity are the norm were naturally interested. Modafinil was commonly used by Ivy League students, physicians, entrepreneurs, CEOs, and even military combatants for a much-needed increase in personal productivity.

Off-label usage of Modafinil continues to rise among young males, according to a new poll of 404 anonymous smart drug users performed in 2020. [3]:

“The number of perceived advantages grew as the reported frequency of modafinil usage increased, but the number of negative effects remained steady and unchanged.”

In addition, respondents felt that advantages outweighed dangers, and that immediate benefits outweighed long-term gains.

…This research has offered insight into the profile of modafinil users, who are primarily male, American or British, educated, employed, and in their mid-20s, at least in this English language study.”

Modafinil was never meant to be used as a weight-loss supplement. Despite this, nootropic users have reported that consistent use of Modafinil caused them to lose weight [4].

But, before we look at whether the “Provigil weight reduction” craze is real, it’s important to understand Modafinil’s safety profile and possible adverse effects [5].

 

 

The Basics of Modafinil for Weight Loss

We’ll oversimplify the science and give you a bare-bones explanation for those of you who don’t know how the body sheds fat tissue.

  • How Do We Shed Pounds?

Caloric intake is the most important factor in weight reduction.

You gain weight when you eat more calories than your body burns because the surplus energy is stored as fat tissue. When you eat less calories than you burn, however, you lose weight because your body utilizes fat tissue to make up for the energy shortfall. And your weight remains the same when your caloric intake matches your body’s caloric burn [6].

In terms of how your body gets rid of fat tissue, the Cleveland Clinic explains fat loss routes in a nutshell [7]:

“A range of intricate metabolic pathways must be used by your body to rid of fat accumulation.”

“…as water, via your skin (sweating) and kidneys (when you urinate).

When you breathe out, carbon dioxide passes through your lungs.”

“…fat breakdown makes energy available for biological activities and physical exercise… It also produces heat, which helps to maintain normal body temperatures.”

There are indeed many other factors that come into play, such as the various ways in which your body burns calories, the type of exercise you do, and the quality & quantity of food you consume. But this simplified model of weight loss will be sufficient enough to explain why nootropic users take Modafinil for weight loss.

  • Is There Evidence of a Link Between Modafinil and Weight Loss?

In the last 15 years, a few research studies have tried to investigate a link between Modafinil and weight reduction in extremely particular clinical situations.

Researchers looked examined how Modafinil and Adderall changed the food consumption of 11 healthy persons between the ages of 21 and 35 in 2004.

While both medicines reduced overall daily calorie consumption, the results were substantially different [8]:

“Modafinil, like amphetamine, reduced food intake and lowered calorie intake while maintaining the percentage of macronutrients ingested.

Although both drugs raise heart rate and blood pressure at larger dosages, the dose of modafinil that reduced food consumption did not substantially raise heart rate.”

Following this study, the researchers speculated that Modafinil may be utilized as a therapy for obesity, calling for further research into those who are overweight or obese.

A 2008 research in shift workers supported similar findings, finding that a daily 400 mg dosage reduced average daily calorie consumption by 38% and reduced hunger perception significantly. The fact that the proportions of lipids, carbs, and proteins ingested did not vary was the most intriguing discovery [9].

In a randomized controlled experiment published in 2016, Modafinil reduced impulsivity in people of normal body weight dramatically.

The primary researcher went on to say the following regarding the study’s consequences for persons who have established an unhealthy food addiction [10]:

“Modafinil has been shown to reduce impulsivity in healthy people, suggesting that it might have an even greater impact on food addicts who lack particular forms of dopamine.”

“This medicine might be very beneficial to those who are failing to manage their appetite while knowing they need to reduce weight.”

“Because the medicine enhances self-control, which is a significant aspect in defining obesity, we believe it will aid in the treatment of the condition.”

However, since its discovery in 2004, Modafinil has piqued attention as a possible solution to the weight gain linked with other medicines used to treat mental health issues:

  • When used with Clozapine, an antipsychotic medicine used to treat schizophrenia, Modafinil caused considerable weight loss [11].
  • Modafinil, when combined with the antipsychotic medicine Olanzapine, resulted in less weight gain than Olanzapine and a placebo drug [12].
  • Modafinil caused significant weight reduction and improved depression symptoms in people with atypical depression, when increased hunger and weight gain are usual consequences. [13]

There are scientific differences over the actuality of “Modafinil weight loss,” since there are research in the medical literature that came to different conclusions.

In one research of narcolepsy patients on Modafinil, the body mass index increased independent of the amount given [14].

Another research completed in 2008 yielded some dubious findings. Despite the fact that Modafinil caused significant weight loss in individuals on atypical antipsychotic drugs, the difference between the patients’ baseline weight and their weight after 12 weeks was similar to that seen in patients taking a placebo [15].

The authors ascribed this strange outcome to weight increase in the placebo group that occurred early in the study:

“These results warrant additional investigation since it’s likely that the placebo group’s maximal weight increase happened at baseline.”

This feature could not be confirmed based on the available data since it was possible that the placebo group took atypicals for longer times than the modafinil group.”

With these findings in mind, let’s look at some potential explanations for why persons who use Modafinil for weight reduction see weight loss.

  • Why Does Modafinil Help You Lose Weight?

Modafinil is not officially authorized for weight reduction, to be clear. This is stated explicitly in the FDA’s related product monograph [16]:

“In placebo-controlled clinical studies, there were no clinically meaningful changes in body weight change in patients treated with PROVIGIL compared to placebo-treated individuals.”

This hasn’t prevented test volunteers from anonymously remarking on their Modafinil-induced indirect weight reduction [17]:

“I’ve dropped around 2-3 pounds in two weeks, but I think it’s due to going to the gym every day and eating better.” Provigil decreased my hunger, helped me go to the gym, and increased my endurance. I already have a problem with my appetite, but provigil made it worse.”

The potential of Modafinil to boost the synthesis of numerous neurotransmitters [18] might be one cause for the lack of appetite.

  • Orexin and histamine are neurotransmitters that control appetite, and high levels of both cause appetite suppression.
  • The potential of modafinil to boost dopamine secretion results in increased motivation, which may help people adhere to their diet and exercise routines more regularly.

Modafinil’s cognitive advantages might be another factor for hunger suppression. The drug’s ability to deliver 8-12 hours of attention is often mentioned by study participants.

There are two natural results in terms of calorie expenditure and nutritional intake when a high degree of focus is given to a particular job…

First, if someone forgets to consume their meals at the appointed times, a calorie deficit develops. Modafinil users are essentially “fasting” until the drug’s effects wear off and the hunger reaction sets in.

Second, because of the significant rise in energy levels, Modafinil users are more likely to be active and move about more during the day. The body burns more calories, contributing to a calorie deficit overall.

Given that Modafinil’s cognitive effects endure for 8-12 hours on average, it’s safe to believe that the circumstances for ingesting less calories while burning more calories are already in place.

In a few phrases, I’ll describe the discussion:

Modafinil DOESN’T DIRECTLY INDUCE FAT/WEIGHT LOSS THROUGH INCREASED METABOLISM OR A UNIQUE MECHANISM OF ACTION THAT TARGETS

Modafinil increases the likelihood of a user doing specific behaviours that are known to contribute to fat/weight reduction on a regular basis.

 

 

Is Losing Weight With Modafinil a Good Idea?

The idea of “Modafinil weight loss” isn’t necessarily incorrect [19]. Modafinil may help with weight reduction by aiding in the regular lifestyle behaviors of a restricted diet, frequent physical activity, uninterrupted sleep, and more.

However, using Modafinil for weight reduction without adopting the aforementioned lifestyle practices would not provide the intended results.

If you want to get the most out of Modafinil’s appetite-suppressing benefits, here are some tips from experienced test volunteers on how to use it safely and effectively:

  • It’s best to have a substantial breakfast before taking Modafinil, since your appetite may be suppressed to the point that you won’t eat anything for the rest of the day.
  • For those who are following an intermittent fasting diet on purpose, the bullet item above may be ignored.
  • Because Modafinil dehydrates the body, it is suggested that you drink at least 2 liters of cold water on days that you take it.

Please keep in mind that the weight loss connected with Modafinil’s cognitive-boosting qualities will be influenced by a number of variables.

These factors include, but are not limited to, dose, medicines that function synergistically with Modafinil, genetics, and the length of time you use Modafinil.

Modafinil should be seen as a complement to, rather than a substitute for, a healthy lifestyle that leads to weight reduction.

 

The Verdict on Modafinil Weight Loss

Modafinil and weight reduction are linked in an indirect way because of many behavioral effects linked to frequent Modafinil usage.

Weight reduction and potentially fat loss may result with hunger suppression combined with tighter adherence to science-backed weight control practices.

Any weight loss that occurs while using Modafinil is only a side effect of the smart drug’s use to boost productivity, cognition, and attention.

Anyone who wants to lose weight and keep it off would benefit greatly from a proven exercise plan, adequate diet, and other weight-loss-friendly lifestyle practices.

 

References

  1. “Modafinil-Associated Weight Loss in a Clozapine-Treated Schizoaffective Disorder Patient,” Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists (US National Library of Medicine), accessed March 14, 2021, https://pubmed.ncbi.nlm.nih.gov/16075662/
  2. MA Kredlow, A Keshishian, S Oppenheimer, and M W Otto. A Systematic Review and Meta-Analysis of Modafinil’s Efficacy as a Cognitive Enhancer 2019;39(5):455-461 in J Clin Psychopharmacol. doi:10.1097/JCP.0000000000001085.
  3. RD Teodorini, N Rycroft, and JH Smith-Spark. An online study assessing perceived hazards and advantages of modafinil usage off-label. doi:10.1371/journal.pone.0227818. PLoS One. 2020;15(2):e0227818.
  4. Modafinil. The date is May 20, 2020. ema.europa.eu
  5. Provigil. rxlist.com (accessed May 20, 2020).
  6. What Is the Average Time to Lose Weight? healthline.com, retrieved May 21, 2020
  7. When you lose weight, where does your body fat go? health.clevelandclinic.org (accessed May 20, 2020).
  8. Wake-promoting drugs with diverse modes of action: a comparison of the effects of modafinil and amphetamine on food intake and cardiovascular activity. Makris AP, Rush CR, Frederich RC, Kelly TH. 42(2):185–195 in Appetite. doi:10.1016/j.appet.2003.11.003.

  9. Modafinil reduces food consumption in people exposed to simulated shift work, according to Perez GA, Haney M, Foltin RW, and Hart CL. doi:10.1016/j.pbb.2008.05.018. Pharmacol Biochem Behav. 2008;90(4):717722.

  10. A narcolepsy drug might aid weight loss in food addicts. sciencedaily.com (accessed May 19, 2020).

  11. Modafinil-associated weight reduction in a clozapine-treated schizoaffective disorder patient, Henderson DC, Louie PM, Koul P, Namey L, Daley TB, Nguyen DD. 2005;17(2):9597. Ann Clin Psychiatry. doi:10.1080/10401230590932407.

  12. JL Roerig, KJ Steffen, JE Mitchell, RD Crosby, BA Gosnell. An investigation on the effects of modafinil on olanzapine-related weight gain in healthy people. 65(7):607-613 in Biol Psychiatry. doi:10.1016/j.biopsych.2008.10.037.

  13. S Vaishnavi, K Gadde, S Alamy, W Zhang, K Connor, JR Davidson. Effects of open-label and double-blind cessation therapy of modafinil for atypical depression. doi:10.1097/01.jcp.0000227700.263.75.39. J Clin Psychopharmacol. 2006;26(4):373-378.

  14. MS Schinkelshoek, IM Smolders, CE Donjacour, and others Sodium oxybate therapy reduced body mass index in narcolepsy type 1 patients. 10.1111/jsr.12684. J Sleep Res. 2019;28(3):e12684.

  15. Sudhakar TP, GP Rao, PL Prasuna, and KJ Vijay Sagar Study investigated the effects of modafinil add-on medication on atypical antipsychotic patients’ severe daytime sleepiness and weight gain. Indian Journal of Psychological Medicine 2008;30:24-31.
  16. [C-IV] PROVIGIL® (modafinil) Tablets The date is May 18, 2020. accessdata.fda.gov
  17. Have you lost weight while on Provigil? The date is May 19, 2020. r/Narcolepsy
  18. Is It Possible To Lose Weight While Using Modafinil? abouttimemagazine.co.uk/ (accessed May 20, 2020).
  19. “Approved and Investigational Uses of Modafinil: an Evidence-Based Review,” Drugs (US National Library of Medicine), https://pubmed.ncbi.nlm.nih.gov/18729534/, accessed March 14, 2021.

 

 

Modafinil and Weight Loss is a guide that covers the use of Modafinil for weight loss. The article includes A-Z information about this topic, including side effects, how to take it, dosage, and more. Reference: average weight loss nuvigil.

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Michael Walshinaldo