Modafinil Dosage Guide | Uses, Indications, and Microdosing

Modafinil is a wakefulness-promoting agent used to treat excessive sleepiness associated with narcolepsy and obstructive sleep apnea. Find out how much modafinil you need for what, who should use it, and more.

Modafinil is a medication that has been used to treat narcolepsy, shift work disorder, and sleep apnea. It is also an effective nootropic. The dosage for modafinil can vary depending on the individual’s needs.

Modafinil Dosage Guide | Uses, Indications, and Microdosing

Are you looking for the ideal Modafinil dose that gives you all the benefits of cognitive enhancement with none of the drawbacks?

You’re not alone yourself. Many smart drug users have been inquiring about the best Modafinil dose they may take for lengthy periods of time.

As a result, various questions are answered…

Is it beneficial to start Modafinil dose at the greatest level until pain occurs? Would it be preferable for a user to start with Modafinil microdosing and gradually increase their dosage?

Is there a Modafinil dose that will make every nootropic user happy?

This post will clarify how to begin considering the correct Modafinil dosage for your productivity requirements.

 

Modafinil.com’s material is provided only for educational and informative reasons. We do not provide legal counsel. We also don’t provide medical advice, diagnosis, or treatment. Please with your doctor before using Modafinil or other nootropics. Our entire Disclaimer and Terms of Use apply to your use of Modafinil.com.

 

What Does Modafinil Mean?

Before we get into the best Modafinil dose, let’s take a look at what Modafinil is and why so many people appear to swear by it.

The FDA-approved wakefulness medicine modafinil (brand name: Provigil) is used to treat narcolepsy, shift work sleep disorder, and obstructive sleep apnea. It does not treat the illnesses directly, but rather the excessive daytime drowsiness that all three disorders are linked with.

Although the exact mechanism of action is unknown, Modafinil is thought to boost the synthesis of various neurotransmitters, including serotonin, histamine, norepinephrine, glutamate, and dopamine [1].

Modafinil was eventually discovered to be utilized off-label as a cognitive enhancer in the early 2000s.

Modafinil provided a considerable improvement in mental function to healthy people who did not suffer from sleep deprivation [2]:

“Pharmaceutical intervention in the sleep–wake cycle was portrayed as a technique to minimize sleep duration, a manner of possibly ‘eliminating sleep,’ and a tool to improve cognitive functions.”

Modafinil was predicted to be the next ‘wonder medication’ to reach the UK, with suggestions that it might become the ‘pharmaceutical equivalent of the electric light bulb,’ prolonging the waking day.”

Modafinil is often utilized as a possible technique of getting ahead of the competition by persons in highly competitive sectors [2].

 

 

Side Effects and Safety Concerns with Modafinil

However, are there any adverse effects to taking a standard Modafinil dosage? To make a smart medicine — or any drug — desirable, the advantages must far exceed the drawbacks.

Fortunately, Modafinil looks to have one of the finest safety profiles of any pharmacological medicine ever introduced in its class. Modafinil’s most prevalent adverse effects are [3]:

  • Headache
  • Nausea
  • Anxiety
  • Sleeping problems
  • Dizziness
  • Mouth/eyes dry

The good news is that these adverse effects are uncommon with correct dose and, when they do occur, they are usually minor. Furthermore, intervention is frequently simple and effective almost immediately (e.g., for dehydration, one simply has to drink more water than usual).

Modafinil is the favored “drug of choice” over conventional stimulants in a number of circumstances since it has less negative effects [4]:

“Compared to typical stimulants, modafinil has less adverse effects such excessive locomotor activity, anxiety, jitteriness, or rebound effects… In addition, [modafinil] is more effective than amphetamine.”

Of course, all of this implies that you are using Modafinil correctly and not abusing it by taking too much of it (and too frequently).

 

The Basics of Modafinil Dosage

Everyone will eventually go on their own “Modafinil dosage” adventure, although the final aim remains the same:

Find the ideal Modafinil dose for achieving the best degree of cognitive improvement for the longest time possible while reducing the risk of suffering undesired side effects.

But this raises two major issues:

  1. What dose of Modafinil should I start with?
  2. What criteria should I use to decide whether to raise or reduce my Modafinil dosage?

Of course, we aren’t licensed to provide medical advise, but we can speak from personal experience, so take what we say with a grain of salt.

Good outcomes have been recorded beginning at 100mg of Modafinil for the first question. We take it first thing in the morning, no later than 9 a.m., to avoid Modafinil interfering with our regular sleep patterns.

(NOTE: It’s critical to avoid taking any medicines other than Modafinil or making major modifications to your normal routine.) Otherwise, outcomes may be jeopardized [5].

We’ll do this 2-3 times each week, with each dosage separated by at least 48 hours. We want to know how you’re feeling and if you’re having any adverse effects while using Modafinil.

After the first 100mg, if we didn’t feel overstimulated or had any negative effects, we would increase the dosage by 25mg for the next week. The assessment procedure would then be rinsed and repeated on a weekly basis.

When we began to experience negative effects and/or felt overstimulated, we reduced the dosage by 25mg for the next week. We’d assess how the reduced Modafinil dose had influenced our mood and cognition once again.

For those who suffer from excessive drowsiness and exhaustion, the Neuroscience Education Institute offers the following dose advice [6]:

More may be beneficial in people with daytime drowsiness in sleep disorders: greater dosages (200–800mg/day) may be better than lower doses (50–200mg/day).

In certain people, lesser dosages (50–200mg/day) may be better than larger doses (200–800mg/day) for focusing and weariness.

As you can see, various users may need different Modafinil dosages to get the desired results.

 

Is There a Standard Modafinil Dose?

The Modafinil dosage that is best for you may not be the same as the drug’s usual prescription dosage.

Modafinil is given at 200mg per day for all of its recognized applications, either in the morning or one hour before commencing a work shift, according to the official FDA product monograph [7]. This is why:

“Doses up to 400mg/day have been well tolerated when given as a single dosage, however there is no consistent evidence that this dose gives extra benefit beyond the 200mg dose.”

Modafinil is available in 100mg and 200mg pills, since some people find that a lesser dose is all they can manage without becoming overwhelmed.

In general, most research and literature have shown that 200mg is the best Modafinil dose for most users, particularly those utilizing the prescription substance as a nootropic.

Keep in mind, however, that 400mg of Modafinil is regarded a maximum dose by doctors. Taking such large doses of Modafinil may cause adverse effects such as anxiety and nausea to become more severe in some people [8].

 

Create your own dosage guidelines | 50-400 mg

If you’re inquisitive about Modafinil or want to adjust your dose, here are some observations we’ve made when experimenting with various dosing protocols:

Modafinil 50 mg dosage

The cognitive gain was moderate for us and only lasted around 2-3 hours.

We’ve found that taking 50mg of Modafinil for 4-6 days per week is more manageable than the 2-3 days per week we’d have to stick to if we were taking 100-200mg at a time.

Furthermore, no negative effects were noted at this Modafinil dose.

However, unless you have a history of being highly sensitive to stimulants, we don’t believe most users would benefit from beginning at this low a dose.

Individuals who perform well on a lesser dose of Modafinil [9] are best described by one Reddit user’s testimonial:

“I find that 50mg works well for me as well. I’d feel overstimulated for a couple of hours, develop a headache, collapse, and feel terrible for the rest of the day on 100-200mg.

50mg, followed by a cup or two of coffee and plenty of water, keeps me going all day and allows me to sleep well at night.”

 

100 milligrams of modafinil

A 100mg Modafinil dose is perhaps our best starting point when we require enhanced attention during a standard “9-5” workday.

This seems to be consistent with prior research, which found that 100mg of Modafinil was enough for most patients to perceive substantial changes in cognitive performance [10].

We find that the gain in cognitive performance begins to wear off approximately 7-8 hours after taking 100mg due to Modafinil’s half-life of 12-15 hours [11].

A few team members do prefer splitting up their daily 100 milligrams of modafinil into two separate doses – 50mg at 7-8am, and the remaining 50mg at 12-1pm.

Continue reading if you don’t notice an improvement in your attention after taking this dose of Modafinil.

 

200 mg modafinil dosage

Most smart drug users who are serious about taking Modafinil to become more energetic and concentrated for the most of the working day use this amount.

It is also the most “well-researched” Modafinil dose, as previously indicated, and it is officially advised in Modafinil’s product monograph for patients who are given the medicine [12]:

“A 200mg daily dosage is advised as a beginning point. According on the physician’s assessment of the patient and the patient’s response, the total daily dosage may be given as a single dose in the morning or as two doses, one in the morning and one at lunch.”

Most users get all of the expected cognitive benefits with minimal to no negative effects at 200mg of Modafinil.

Most Modafinil users respond well to this dosage when taken 1-3 times per week. There doesn’t seem to be any scientific proof that taking more than 200mg of Modafinil provides extra advantages, or that dividing your Modafinil intake into two 100mg doses makes a significant impact.

 

300 milligrams of modafinil

We wouldn’t take a 300mg dosage of Modafinil unless we definitely needed an extra 1-2 hours of attention or planned to remain up for more than 24 hours.

We had significant difficulties falling asleep before 3-4am, even despite taking this amount early in the morning, and awoke feeling “somewhat hungover” the following morning.

Although the research on this Modafinil dose is limited, several studies provide many recommendations that are consistent with findings.

Using 300mg of Modafinil to power through sleep deprivation decreased performance the following day, according to one research comparing varying levels of Modafinil dose to 100mg of caffeine [13]:

“Enhanced performance with modafinil during overnight work varied with dose (200mg > 100mg; 300, 400mg > 200, 100mg, caffeine).

The enhancement was diminished at the maximum dosage (300mg) in the assessment of next-day performance due to the larger disruption of preceding sleep.”

In another trial, 300mg of Modafinil was the only amount that permitted French military troops who had been deprived of sleep for 64 hours to retain their cognitive function compared to baseline levels [14].

Consider dividing the daily dose of Modafinil into two smaller doses: 150mg in the morning and 150mg after lunch if you opt to utilize this amount.

 

400 mg modafinil dosage

We observed that utilizing this dosage for cognitive enhancement did not result in any performance advantage over our 300mg regimen or even a one-time 200mg treatment. 

Patients with shift work sleep problem, narcolepsy, or sleep apnea should not take more than 400mg of Modafinil per day, according to doctors [15].

We believe there are just a few occasions in which 400mg of Modafinil is necessary to improve cognition:

  • Modafinil is removed at a higher pace due to its unique metabolism.
  • Modafinil users who have acquired a strong tolerance (to which we would rather advise an extended break from Modafinil) 
  • Users of smart drugs who are exceptionally huge in stature 

At this high dosage of Modafinil, we noticed a greater frequency and severity of side effects, such as brain fog, persistent weariness, difficulties focusing, reduced energy levels, and so on.

Furthermore, the benefits of Modafinil wear off fast, perhaps leading to an overestimation of your own mental capacity [16]:

“In circumstances of moderate sleep deprivation, a single dosage of modafinil seems to have a cognitive boosting impact.” It does not seem to improve cognitive function over a longer time of sleep deprivation in repeated doses, but merely preserves awake.”

In conclusion, unless you have a therapeutic need for 400mg of Modafinil, we recommend that you avoid it.

 

Modafinil microdosing

Taking 1/5th to 1/10th of the usual Modafinil dose is known as “Modafinil microdosing.” In practice, a microdose of Modafinil is defined as 50mg or less of the drug.

Many people who feel that a 100 milligrams of modafinil is “too much” may find much smaller doses to be more tolerable. They can still experience the positive aspects of Modafinil without experiencing any side effects whatsoever.

In a Reddit forum discussing the benefits of Modafinil microdosing, one user chimed in with their success in taking 12.5mg of Modafinil per day [17]:

“There are no residual side effects with microdoses, and usage on successive days is more beneficial.”

Bottom line, this thing has virtually saved my life by enabling me to work constantly and successfully while maintaining attention for a lengthy period of time.”

Modafinil microdosing may also be useful if you suffer from liver issues or happen to be 65 years or older [18].

If you want to start with very low doses of Modafinil and work your way up to a higher microdose, one smart drug user suggested the following regimen to assist them discover their perfect dosage of 70mg per day [19]:

  • Days 1-3: Take 25mg of Modafinil every day at the same time.
  • 4-6 days: Three-day break
  • Days 7-9: Take 50mg of Modafinil every day at the same time.
  • Three-day break on days 10-12

Repeat the “three day on, three day off” cycle with increasing dosages until you discover your ideal Modafinil dosage.

 

 

Dosage Lethal?

Under the “Overdosage” section of the official Modafinil drug guide [20], you’ll find the following blurb:

“In clinical studies, 32 patients received a total of 151 protocol-specified doses ranging from 1000 to 1600mg/day (5 to 8 times the recommended daily dosage of 200mg), including 13 subjects who got doses of 1000 or 1200mg/day for 7 to 21 days.

Furthermore, there were many deliberate acute overdoses, the two greatest of which were 4500mg and 4000mg taken by two people engaging in international depression trials. There were no unexpected or life-threatening consequences in any of the research participants.”

Chest discomfort, increased blood pressure, irregular pulse, psychosis, extreme agitation, and general restlessness are common adverse effects of Modafinil overdose.

To put it all into perspective: Modafinil’s “LD50,” or the amount necessary to kill half of all test subjects, is 1.0-1.25 g/kg in mice given it orally [21]. So, for a 70 kilogram (155lb) guy, 75 grams of Modafinil would be required for the smart medication to be declared lethal!

Nobody has ever been caught with more than 12 grams of Modafinil in one day.

 

The Verdict on Modafinil Dosing

You now have all of the information you need to figure out how much Modafinil to take for your nootropic requirements.

Although research papers and observations are basic and easy, here’s a brief reminder of everything we addressed in this article:

Users who do not have a history of substance misuse and are new to smart medicines should start with a 100mg dose and progressively increase to 200mg. Many people have experienced improved memory, attention, and productivity after following this approach – without many of the unpleasant side effects.

Users who are hypersensitive to stimulants and prefer to use Modafinil more often throughout the week, on the other hand, may benefit from a daily microdose of 50mg or less.

 

References

  1. MA Kredlow, A Keshishian, S Oppenheimer, and M W Otto. A Systematic Review and Meta-Analysis of Modafinil’s Efficacy as a Cognitive Enhancer 2019;39(5):455-461 in J Clin Psychopharmacol. doi:10.1097/JCP.0000000000001085

  2. Modafinil in the media: analogies, medicalization, and the body. Coveney CM, Nerlich B, Martin P. doi:10.1016/j.socscimed.2008.11.016. Soc Sci Med. 2009;68(3):487-495.
  3. PROVIGIL. rxlist.com, retrieved on June 7, 2020
  4. Modafinil, a new awakening medication, in practice and danger. Kim D. 10.5620/eht.2012.27.e2012007
  5. Principles of Safe Nootropic Use to Boost Your Brain psychologytoday.com (accessed June 5, 2020).
  6. MODAFINIL. cdn.neiglobal.com Retrieved June 6, 2020
  7. [C-IV] PROVIGIL® (modafinil) Tablets The date is June 5, 2020. accessdata.fda.gov
  8. RJ Broughton, JA Fleming, CF George, and others Modafinil in the treatment of excessive daytime sleepiness in narcolepsy: a randomized, double-blind, placebo-controlled crossover study 444-451 in Neurology, 1997, doi:10.1212/wnl.49.2.444.

  9. Just a friendly reminder to try 50mg modafinil. The date is June 7, 2020. r/afinil

  10. LC Wittkampf, J Arends, L Timmerman, M Lancel. A review of modafinil and armodafinil as add-on treatment in schizophrenia patients on antipsychotics. doi:10.1177/2045125312441815 Ther Adv Psychopharmacol. 2012;2(3):115-125.

  11. I. Taneja, A. Diedrich, B.K. Black, D.W. Byrne, S.Y. Paranjape, and others Modafinil activates the sympathomedullary system. 2005;45(4):612-618 in Hypertension. doi:10.1161/01.HYP.0000158267.66763.63

  12. Provigil 100 mg Modafinil Tablets medicines.org.uk (accessed June 4, 2020).

  13. C. Turner, A. J. Belyavin, and A. N. Nicholson. Human studies on sleep and wakefulness revealed the duration of activity and manner of action of modafinil. 2014;28(7):643-654 in J Psychopharmacol. doi:10.1177/0269881113508173

  14. JV Baranski, V Gil, T McLellan, D Moroz, A Buguet, and others Modafinil’s Effects on Cognitive Performance in a Warm Environment After 40 Hours of Sleep Deprivation Mil Psychol 14(1):23-47, 2002. doi:10.1207/s15327876mp1003 3.
  15. drug summary for modafinil pdr.net (retrieved 6 June 2020).
  16. Modafinil and methylphenidate for neuroenhancement in healthy people: A systematic study. Repantis D, Schlattmann P, Laisney O, Heuser I. 62(3):187-206 in Pharmacol Research. doi:10.1016/j.phrs.2010.04.002

  17. Microdosing. The date is June 8, 2020. r/modafinil

  18. Provigil is an anti-anxiety medication (modafinil). medicalnewstoday.com (accessed June 3, 2020).
  19. Dosage of Modafinil – A Complete Guide 2017. slideshare.net was accessed on June 5, 2020.
  20. Modafinil Tablets Medication Guide parpharm.com (accessed June 2, 2020).
  21. A Critical Review of Modafinil Properties and Analytical, Bioanalytical Methods for Its Determination, Ramachandra B. 2016;46(6):482-489; doi:10.1080/10408347.2016.1153948.

 

 

Modafinil is a medication that is used to treat narcolepsy, sleep apnea, and shift work sleep disorder. It can also be used as a cognitive enhancer, especially for people with depression. The dosage guide will provide information on how much to take for each condition. Reference: modafinil dosage for depression.

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Michael Walshinaldo